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ProSource: October 2013

Q & A: Was Everything I Learned About Muscle Force Generation Actually Wrong?

By Lance C. Dalleck, Ph.D., and Nicole J. Somerville, B.Ph.Ed. 

Q: I just heard about a new study suggesting that what was previously thought about muscle force generation—specifically, the sliding filament theory—is actually wrong? Is this true? And if so, how does this affect the types of programs I design for my clients?

A: The research you refer to, conducted by Williams and colleagues (2013), found that muscle force generation is much more intricate than has been historically taught over the past 50 years. Historically, muscle force generation has been explained by the sliding filament theory. This novel new study, however, uncovered that muscle force is generated in all directions, and not just along the myosin/actin axis.

Before forging ahead, it might be helpful to review the following chart for a quick refresher on common skeletal muscle contraction terminology. Keep in mind that this is a fairly technical subject, but one with some practical implications for fitness professionals (which are discussed at the end). 

Skeletal Muscle Contraction Terminology

Sarcolemma

Cell wall of the muscle cell

T-tubules

Channels within the muscle cell containing fluid to transmit nerve impulses to the Z-band

Ca2+

Calcium ion

Sarcoplasmic reticulum

Membranous channel within the muscle cell that releases calcium ions, causing muscle contraction

Troponin

Protein that lies within the groove between actin filaments in muscle tissue

Tropomyosin

Protein that blocks the attachment site for the myosincross bridge

Actin

Protein that forms the thinner filaments found in the lighter I-band

Myosin

Protein that forms the thicker filaments found in the darker A-band

ATP (Adenosine triphosphate)

Main energy source that cells use for most of their work. Releases energy when splitting into ADP and Pi


Old-school Understanding of Skeletal Muscle Contraction

Muscle contraction involves a continuous four-step cycle called the sliding filament theory. Initially, an action potential is generated, which travels down the sarcolemma into the t-tubules. This action potential causes Ca2+ ions to be released from the sarcoplasmic reticulum. These free Ca2+ ions bind to troponin, causing it to remove tropomyosin, which blocks the active actin sites. ATP then binds to the myosin head. When the ATP separates into ADP and Pi, it causes a change in the myosin head form allowing it to attach to actin. When Pi is released, actin pulls on the myosin causing a contraction, also known as the power stroke. This cycle is repeated simultaneously across all muscle fibers for a muscle contraction. Ca2+ is actively removed after the action potential ends, causing tropomyosin to re-block the actin causing the contraction to end (Patton and Thibodeu, 2009). The binding of actin to myosin is essential in muscle force generation and consequently they must overlap to attach to one another.

This sliding filament theory is supported by the length-tension relationship, which was proposed in the 1960s (Gordon, Huxley and Julian, 1966). The length-tension relationship explains the force that can be produced at different fiber lengths. The length of the fiber depends on the position of both actin and myosin filaments within the sarcomeres that make up a muscle fiber. When a muscle fiber is stretched, and there is minimal overlap of actin and myosin, the contraction force is small. Similar force production is also seen at the other end of the spectrum, when there is maximal overlap of actin and myosin. However, when there is optimal overlap between actin and myosin, the amount of force that can be produced is maximal (Patton and Thibodeu, 2009). This relationship is currently the primary way of examining how muscle force changes due to the change in actin and myosin overlap, and has been the current way of thinking for the past 50 years.

New Insights Into Skeletal Muscle Contraction

As seen above, the length-tension curve has focused simply on the overlap between actin and myosin (i.e., only looking in one direction). However, it is well known that a contracting muscle is isovolumetric, which means that the muscle must grow in width when it contracts. Consequently as the muscle expands the distance between myosin and actin increases. This distance is called lattice spacing. The length-tension curve has traditionally only been based on the overlap between actin and myosin. New technology, computational power and the ability to validate the computer results through X-ray diffraction has allowed researchers to examine the change in force production depending on the lattice spacing. This change in lattice spacing at different muscle lengths seems to have an effect on the change in muscle force.

When the lattice spacing is held constant, the actin/myosin filament overlap reduces the steepness of the length-tension curve—changing how much force can be generated by about half, as seen in Figure 1. The change in lattice spacing is responsible for the rest of the force production, as was seen when the actin/myosin filament overlap was held constant. This increase in distance, due to the isovolumetric nature of muscle, causes the myosin head to attach at sharper angles over a greater distance. This indicates that muscle force production is multiaxial (along the axis of the muscle and the radial direction) and not just along one axis, as was previously believed.

Figure 1. Isolattice, isovolumetric and isolength force curves. Green represents where lattice spacing is held constant and only sarcomere length is changed. Yellow represents where sarcomere length is kept the same and lattice spacing is changed. Red represents when the muscle volume is kept the same and both sarcomere length and lattice spacing are changed to keep this constant. This shows that both lattice spacing and sarcomere length are mutually dependent, as they both change the force production.


What Does All This Mean for Fitness Professionals?

While these latest research findings are intriguing, it is important that fitness professionals view them in the same vein as scientists—that these results are preliminary and not without limitations. Most notably, in the current study researchers examined isolated insect muscle fibers rather than intact whole human skeletal muscle. It therefore remains unclear whether the same phenomenon observed in the present study exists in human muscle fiber types and/or different skeletal muscle fiber types (e.g., Type I and Type II).

Nevertheless, these initial findings will certainly generate additional scientific inquiry and likely lead to a variety of practical applications for fitness professionals in their work with clients. These include:

  • Our understanding of skeletal muscle fatigue and training strategies to combat fatigue could be enhanced.
  • Our knowledge of the health ramifications associated with age-related reductions in skeletal muscle may be improved. Undoubtedly, this would lead to superior training programs that better preserve skeletal muscle over the course of the lifespan.
  • Our understanding of gender differences in skeletal muscle structure and function may be strengthened. This could have important implications for the design of more individualized training programs.
  • Our knowledge of skeletal muscle training adaptations and how these relate to performance may be expanded considerably.

Stay tuned on this topic, as we will learn much more in the coming years!

References

Gordon, A., Huxley, A. and Julian, F. (1966). The variation in isometric tension with sarcomere length in vertebrate muscle fiber. The Journal of Physiology, 184, 170-192.

Patton, K. and Thibodeau, G. (2009). Anatomy & Physiology (7th ed.). Maryland Heights: Mosby.

Williams, C. et al. (2013). The length-tension curve in muscle depends on lattice spacing. Proceedings of the Royal Society B: Biological Sciences, 280, 1766, 20130697 DOI: 10.1098/rspb.2013.0697.

______________________________________________________________________

Lance C. Dalleck, PhD, ACSM-RCEP®, is an Assistant Professor of Exercise and Sport Science at Western State Colorado University. His research interests include improving exercise performance and health outcomes through evidence-based practice, quantifying the energy expenditure of outdoor and non-traditional types of physical activity, and studying historical perspectives in health, fitness and exercise physiology. 

Nicole Somerville is a current master’s student at the University of Auckland in New Zealand. She is currently examining the effects of exercise training intensity on cardiovascular disease risk factors in middle-age men and women at risk for cardiovascular disease. Her primary research interests are focused on primordial, primary and secondary prevention of cardiovascular disease through an evidence-based practice approach.

 

 

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